Article
Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors.
Oncogene - 1 Aug 2021
Casillas Andrea L, Chauhan Shailender S, Toth Rachel K, Sainz Alva G, Clements Amber N, Jensen Corbin C, Langlais Paul R, Miranti Cindy K, Cress Anne E, Warfel Noel A
Abstract excerpt
Angiogenesis is essential for the sustained growth of solid tumors. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of angiogenesis and constitutive activation of HIF-1 is frequently observed in human cancers. Therefore, understanding the mechanisms governing the activation of HIF-1 is critical for successful therapeutic targeting of tumor angiogenesis. Herein, we establish a new regulatory mechanism...
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