Article
Reactive oxygen generated by Nox1 triggers the angiogenic switch.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jan 2002
Arbiser Jack L, Petros John, Klafter Robert, Govindajaran Baskaran, McLaughlin Elizabeth R, Brown Lawrence F, Cohen Cynthia, Moses Marsha, Kilroy Susan, Arnold Rebecca S, Lambeth J David
Abstract excerpt
The reactive oxygen-generating enzyme Nox1 transforms NIH 3T3 cells, rendering them highly tumorigenic and, as shown herein, also increases tumorigenicity of DU-145 prostate epithelial cells. Although Nox1 modestly stimulates cell division in both fibroblasts and epithelial cells, an increased mitogenic rate alone did not account fully for the marked tumorigenicity. Herein, we show that Nox1 is a potent trigger...
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