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Article

Differential phosphorylation of LZ+/LZ- MYPT1 isoforms regulates MLC phosphatase activity.

Archives of biochemistry and biophysics - 15 Nov 2014

Yuen Samantha L, Ogut Ozgur, Brozovich Frank V

Abstract excerpt

The vascular response to NO is due, in part, to a Ca(2+) independent activation of myosin light chain (MLC) phosphatase, a trimeric enzyme of 20kDa, 38kDa catalytic and 110-130kDa myosin targeting (MYPT1) subunits. Alternative mRNA splicing produces MYPT1 isoforms that differ by the presence or absence of a central insert (CI) and a leucine zipper (LZ), and the presence of a LZ+ MYPT1 isoform is important for...

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Identifiers

PMID: 25168281
DOI: 10.1016/j.abb.2014.08.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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