Article
Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration.
The Journal of biological chemistry - 20 Dec 2013
Ranayhossaini Daniel J, Rodriguez Andres I, Sahoo Sanghamitra, Chen Beibei B, Mallampalli Rama K, Kelley Eric E, Csanyi Gabor, Gladwin Mark T, Romero Guillermo, Pagano Patrick J
Abstract excerpt
Excessive vascular and colon epithelial reactive oxygen species production by NADPH oxidase isoform 1 (Nox1) has been implicated in a number of disease states, including hypertension, atherosclerosis, and neoplasia. A peptide that mimics a putative activation domain of the Nox1 activator subunit NOXA1 (NOXA1 docking sequence, also known as NoxA1ds) potently inhibited Nox1-derived superoxide anion (O2·-)...
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