Article

Targeting the Cx43 Carboxyl Terminal H2 Domain Preserves Left Ventricular Function Following Ischemia-Reperfusion Injury

2019-06-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> αCT1 is a 25 amino acid therapeutic peptide incorporating the Zonula Occludens-1 (ZO-1)-binding domain of connexin43 (Cx43) that is currently in Phase III clinical testing for healing chronic skin wounds. In preclinical studies in mice, we reported that αCT1 reduces arrhythmias and improves ventricular function following cardiac injury, effects that were accompanied by incre...

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Literature Corpus work: 6dc8383f-20fb-573b-ab5e-2ea980385951
DOI: 10.1101/668509

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