Article
The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo.
The Journal of clinical investigation - 1 Jul 2007
Atochin Dmitriy N, Wang Annie, Liu Victor W T, Critchlow Jeffrey D, Dantas Ana Paula V, Looft-Wilson Robin, Murata Takahisa, Salomone Salvatore, Shin Hwa Kyoung, Ayata Cenk, Moskowitz Michael A, Michel Thomas, Sessa William C, Huang Paul L
Abstract excerpt
NO plays critical roles in vascular function. We show that modulation of the eNOS serine 1179 (S1179) phosphorylation site affects vascular reactivity and determines stroke size in vivo. Transgenic mice expressing only a phosphomimetic (S1179D) form of eNOS show greater vascular reactivity, develop less severe strokes, and have improved cerebral blood flow in a middle cerebral artery occlusion model than mice...
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