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Article

Impact of Nox5 polymorphisms on basal and stimulus-dependent ROS generation.

PloS one - 1 Jan 2014

Wang Yusi, Chen Feng, Le Brian, Stepp David W, Fulton David J R

Abstract excerpt

Nox5 is an EF-hand containing, calcium-dependent isoform of the NADPH oxidase family of reactive oxygen species (ROS) generating enzymes. Altered expression and activity of Nox5 has been reported in cardiovascular diseases and cancers but the absence of Nox5 in rodents has precluded a greater understanding of its physiological and pathophysiological roles. Multiple polymorphisms have been identified within the...

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Identifiers

PMID: 24992705
DOI: 10.1371/journal.pone.0100102
PMCID: PMC4081039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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