Blockade of redox second messengers inhibits JAK/STAT and MEK/ERK signaling sensitizing FLT3-mutant acute myeloid leukemia to targeted therapies

Abstract excerpt

FLT3-mutations are diagnosed in 25-30% of patients with acute myeloid leukemia (AML) and are associated with a poor prognosis. AML is associated with the overproduction of reactive oxygen species (ROS), which drives genomic instability through the oxidation of DNA bases, promoting clonal evolution, treatment resistance and poor outcomes. ROS are also important second messengers, triggering cysteine oxidation in re...

Topics

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• Cell Line, Tumor
• Cysteine
• Disease Models, Animal
• fms-Like Tyrosine Kinase 3
• Leukemia, Myeloid, Acute
• Mice
• Protein Kinase Inhibitors
• Reactive Oxygen Species

Identifiers and source

Literature Corpus work

1e6ef677-a3d1-5794-acc6-48c7385d0023

DOI

10.1101/2022.03.09.483687