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Article

Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases.

Molecular and cellular biology - 1 Mar 2006

Ueyama Takehiko, Geiszt Miklós, Leto Thomas L

Abstract excerpt

Several Nox family NADPH oxidases function as multicomponent enzyme systems. We explored determinants of assembly of the multicomponent oxidases Nox1 and Nox3 and examined the involvement of Rac1 in their regulation. Both enzymes are supported by p47phox and p67phox or homologous regulators called Noxo1 and Noxa1, although Nox3 is less dependent on these cofactors for activity. Plasma membrane targeting of Noxa1...

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Identifiers

PMID: 16507994
DOI: 10.1128/MCB.26.6.2160-2174.2006
PMCID: PMC1430270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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