Article
MKK6 phosphorylation regulates production of superoxide by enhancing Rac GTPase activity.
Antioxidants & redox signaling - 1 Nov 2007
Harraz Maged M, Park Andrea, Abbott Duane, Zhou Weihong, Zhang Yulong, Engelhardt John F
Abstract excerpt
Rac-dependent NADPH oxidases generate reactive oxygen species used in cell signaling and microbial killing or both. Whereas the mechanisms leading to NADPH oxidase activation are fairly well studied, the mechanisms that control downregulation of this enzyme complex remain unclear. We hypothesized that reactive oxygen species produced by NADPH oxidase may autoregulate the complex by inhibiting Rac activity. To...
Topics
- Adenoviridae
- Animals
- Cell Line
- Cells, Cultured
- Escherichia coli
- Gene Expression Regulation, Enzymologic
- Glutathione Transferase
- Hydrogen Peroxide
- MAP Kinase Kinase 6
- Macrophages
- Mice
- Mice, Transgenic
- Mutation
- Oxidants