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Article

MKK6 phosphorylation regulates production of superoxide by enhancing Rac GTPase activity.

Antioxidants & redox signaling - 1 Nov 2007

Harraz Maged M, Park Andrea, Abbott Duane, Zhou Weihong, Zhang Yulong, Engelhardt John F

Abstract excerpt

Rac-dependent NADPH oxidases generate reactive oxygen species used in cell signaling and microbial killing or both. Whereas the mechanisms leading to NADPH oxidase activation are fairly well studied, the mechanisms that control downregulation of this enzyme complex remain unclear. We hypothesized that reactive oxygen species produced by NADPH oxidase may autoregulate the complex by inhibiting Rac activity. To...

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Identifiers

PMID: 17854274
DOI: 10.1089/ars.2007.1579
PMCID: PMC3597076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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