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Article

Mitochondrial localization of the OAS1 p46 isoform associated with a common single nucleotide polymorphism.

BMC cell biology - 9 Sept 2014

Kjær Karina Hansen, Pahus Jytte, Hansen Mariann Fagernæs, Poulsen Jesper Buchhave, Christensen Erik Ilsø, Justesen Just, Martensen Pia Møller

Abstract excerpt

BACKGROUND: The expression of 2'-5'-Oligoadenylate synthetases (OASs) is induced by type 1 Interferons (IFNs) in response to viral infection. The OAS proteins have a unique ability to produce 2'-5' Oligoadenylates, which bind and activate the ribonuclease RNase L. The RNase L degrades cellular RNAs which in turn inhibits protein translation and induces apoptosis. Several single nucleotide polymorphisms (SNPs) in...

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Identifiers

PMID: 25205466
DOI: 10.1186/1471-2121-15-33
PMCID: PMC4165621

Genes

OAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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