A functional variant in the OAS1 gene is associated with Sjögren's syndrome complicated with HBV infection.

doi:10.1038/s41598-017-17931-9

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Article

A functional variant in the OAS1 gene is associated with Sjögren's syndrome complicated with HBV infection.

Scientific reports - 14 Dec 2017

Liu Xianjun, Xing Hongcun, Gao Wenjing, Yu Di, Zhao Yuming, Shi Xiaoju, Zhang Kun, Li Pingya, Yu Jiaao, Xu Wei, Shan Hongli, Zhang Kaiyu, Bao Wanguo, Fu Xueqi, Yang Sirui, Wang Shaofeng

Abstract excerpt

Hepatitis B virus (HBV) has been suspected to contribute to several autoimmune diseases, including Sjögren's syndrome (SS), although the exact mechanism is unknown. The 2'-5' oligoadenylate synthetase (OAS1) is one of the most important components of the immune system and has significant antiviral functions. We studied a polymorphism rs10774671 of OAS1 gene in Han Chinese descent. The minor allele G was...

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PMID: 29242559
DOI: 10.1038/s41598-017-17931-9
PMCID: PMC5730593

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OAS1

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A functional variant in the OAS1 gene is associated with Sjögren's syndrome complicated with HBV infection.PMID 29242559Read ↗

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