Differential effects of a common splice site polymorphism on the generation of OAS1 variants in human bronchial epithelial cells.

doi:10.1016/j.humimm.2012.11.011

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Article

Differential effects of a common splice site polymorphism on the generation of OAS1 variants in human bronchial epithelial cells.

Human immunology - 1 Mar 2013

Noguchi Satoshi, Hamano Emi, Matsushita Ikumi, Hijikata Minako, Ito Hideyuki, Nagase Takahide, Keicho Naoto

Abstract excerpt

The 2',5'-oligoadenylate synthetase 1 (OAS1) is one of the major interferon-inducible proteins and a critical component of the host defense system against viral infection. A single nucleotide polymorphism (SNP), rs10774671, presumably responsible for alternate splicing of this gene, has frequently been associated with a variety of viral diseases, including emerging respiratory infections. We investigated the...

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Identifiers

PMID: 23220500
DOI: 10.1016/j.humimm.2012.11.011
PMCID: PMC7115495

Genes

OAS1

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Differential effects of a common splice site polymorphism on the generation of OAS1 variants in human bronchial epithelial cells.PMID 23220500Read ↗

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