Article
Variation in antiviral 2',5'-oligoadenylate synthetase (2'5'AS) enzyme activity is controlled by a single-nucleotide polymorphism at a splice-acceptor site in the OAS1 gene.
American journal of human genetics - 1 Apr 2005
Bonnevie-Nielsen Vagn, Field L Leigh, Lu Shao, Zheng Dong-Jun, Li Min, Martensen Pia M, Nielsen Thomas B, Beck-Nielsen Henning, Lau Yu-Lung, Pociot Flemming
Abstract excerpt
It is likely that human genetic differences mediate susceptibility to viral infection and virus-triggered disorders. OAS genes encoding the antiviral enzyme 2',5'-oligoadenylate synthetase (2'5'AS) are critical components of the innate immune response to viruses. This enzyme uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates, which activate latent...
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