Article
Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons.
PLoS genetics - 1 Jun 2017
Li He, Reksten Tove Ragna, Ice John A, Kelly Jennifer A, Adrianto Indra, Rasmussen Astrid, Wang Shaofeng, He Bo, Grundahl Kiely M, Glenn Stuart B, Miceli-Richard Corinne, Bowman Simon, Lester Sue, Eriksson Per, Eloranta Maija-Leena, Brun Johan G, Gøransson Lasse G, Harboe Erna, Guthridge Joel M, Kaufman Kenneth M, Kvarnström Marika, Cunninghame Graham Deborah S, Patel Ketan, Adler Adam J, Farris A Darise, Brennan Michael T, Chodosh James, Gopalakrishnan Rajaram, Weisman Michael H, Venuturupalli Swamy, Wallace Daniel J, Hefner Kimberly S, Houston Glen D, Huang Andrew J W, Hughes Pamela J, Lewis David M, Radfar Lida, Vista Evan S, Edgar Contessa E, Rohrer Michael D, Stone Donald U, Vyse Timothy J, Harley John B, Gaffney Patrick M, James Judith A, Turner Sean, Alevizos Ilias, Anaya Juan-Manuel, Rhodus Nelson L, Segal Barbara M, Montgomery Courtney G, Scofield R Hal, Kovats Susan, Mariette Xavier, Rönnblom Lars, Witte Torsten, Rischmueller Maureen, Wahren-Herlenius Marie, Omdal Roald, Jonsson Roland, Ng Wan-Fai, Nordmark Gunnel, Lessard Christopher J, Sivils Kathy L
Abstract excerpt
Sjögren's syndrome (SS) is a common, autoimmune exocrinopathy distinguished by keratoconjunctivitis sicca and xerostomia. Patients frequently develop serious complications including lymphoma, pulmonary dysfunction, neuropathy, vasculitis, and debilitating fatigue. Dysregulation of type I interferon (IFN) pathway is a prominent feature of SS and is correlated with increased autoantibody titers and disease...
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