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Article

2'-5' oligoadenylate synthetase 1 polymorphism is associated with prostate cancer.

Cancer - 15 Dec 2011

Mandal Sanjay, Abebe Fisseha, Chaudhary Jaideep

Abstract excerpt

BACKGROUND: The antiviral, proapoptotic, antiproliferative gene 2'-5' oligoadenylate synthetase (2-5OAS1) converts adenosine triphosphate into a series of 2'-5' oligoadenylates (2-5A). In turn, 2-5A activates latent ribonuclease (RNaseL), a candidate hereditary prostate cancer gene. OAS1 polymorphism (reference single nucleotide polymorphism [SNP] 2660 [rs2660]) has been associated with increased susceptibility...

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Source

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Identifiers

PMID: 21638280
DOI: 10.1002/cncr.26219
PMCID: PMC3167978

Genes

OAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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