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Article

SUR1-mutant iPS cell-derived islets recapitulate the pathophysiology of congenital hyperinsulinism.

Diabetologia - 1 Mar 2021

Lithovius Väinö, Saarimäki-Vire Jonna, Balboa Diego, Ibrahim Hazem, Montaser Hossam, Barsby Tom, Otonkoski Timo

Abstract excerpt

AIMS/HYPOTHESIS: Congenital hyperinsulinism caused by mutations in the KATP-channel-encoding genes (KATPHI) is a potentially life-threatening disorder of the pancreatic beta cells. No optimal medical treatment is available for patients with diazoxide-unresponsive diffuse KATPHI. Therefore, we aimed to create a model of KATPHI using patient induced pluripotent stem cell (iPSC)-derived islets. METHODS: We derived...

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PMID: 33404684
DOI: 10.1007/s00125-020-05346-7

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