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Article

Pancreatic β-cell KATP channels: Hypoglycaemia and hyperglycaemia.

Reviews in endocrine & metabolic disorders - 1 Sept 2010

Bennett Kate, James Chela, Hussain Khalid

Abstract excerpt

The pancreatic β-cell ATP-sensitive K(+) channel (K(ATP) channel) plays a critical role in glucose homeostasis by linking glucose metabolism to electrical excitability and insulin secretion. Changes in the intracellular ratio of ATP/ADP mediate the metabolic regulation of channel activity. The β-cell K(ATP) channel is a hetero-octameric complex composed of two types of subunits: four inward-rectifying potassium...

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Source

Identifiers

PMID: 20878482
DOI: 10.1007/s11154-010-9144-2

Genes

ABCC8
KCNJ11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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