Article

Mature and immature β-cells both contribute to islet function and insulin release

2020-07-21

Abstract excerpt

<title>Abstract</title> <p>Transcriptionally mature and immature β-cells co-exist within the adult islet. How such diversity contributes to insulin release remains poorly understood. Here we show that differences in β-cell maturity, defined using PDX1 and MAFA expression, are required for proper islet operation. Functional mapping of rodent and human islets containing proportionally more mature β-cells revealed d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cd86ef17-c00f-5dcb-a1b8-4c32dd162a3b
DOI: 10.21203/rs.3.rs-40718/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mature and immature β-cells both contribute to islet function and insulin releaseDOI 10.21203/rs.3.rs-40718/v1Read

Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2DSemantic proximity Read

Functional, metabolic and transcriptional maturation of stem cell derived beta cellsSemantic proximity Read

A transcriptional cross species map of pancreatic islet cellsSemantic proximity Read

Linking molecular pathways and islet cell dysfunction in human type 1 diabetesSemantic proximity Read

Pancreatic β-cell heterogeneity in health and diabetes: classes, sources, and subtypes.Semantic proximity Read

AFF3 and BACH2 are master regulators of metabolic inflexibility, β/α-cell transition, and dedifferentiation in type 2 diabetesSemantic proximity Read

Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation stateSemantic proximity Read

DEC1 Regulates Human β Cell Functional Maturation and Circadian RhythmSemantic proximity Read

Kinetics and genomic profiling of adult human and mouse β-cell maturationSemantic proximity Read

Temporal Transcriptome Analysis Reveals Dynamic Gene Expression Patterns Driving β-Cell MaturationSemantic proximity Read

Maturation of beta cells: lessons from in vivo and in vitro modelsSemantic proximity Read

Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after TransplantationSemantic proximity Read