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Article

Preservation of Reduced Numbers of Insulin-Positive Cells in Sulfonylurea-Unresponsive KCNJ11-Related Diabetes.

The Journal of clinical endocrinology and metabolism - 1 Jan 2017

Greeley Siri Atma W, Zielinski Mark C, Poudel Ananta, Ye Honggang, Berry Shivani, Taxy Jerome B, Carmody David, Steiner Donald F, Philipson Louis H, Wood Jamie R, Hara Manami

Abstract excerpt

Context: The most common genetic cause of permanent neonatal diabetes mellitus is activating mutations in KCNJ11, which can usually be treated using oral sulfonylureas (SUs) instead of insulin injections, although some mutations are SU unresponsive. In this work, we provide a report of the pancreatic islet endocrine cell composition and area in a patient with an SU-unresponsive KCNJ11 mutation (p.G334D), in...

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Identifiers

PMID: 27802092
DOI: 10.1210/jc.2016-2826
PMCID: PMC5413092

Genes

KCNJ11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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