Article

Pancreatic islets undergo functional and morphological adaptation during development of Barth Syndrome

2024-07-02

Abstract excerpt

Barth syndrome is a multisystem genetic disorder caused by mutation in TAFAZZIN , a gene that encodes a phospholipid:lysophospholipid transacylase important for cardiolipin remodeling. Barth Syndrome patients suffer from a number of symptoms including early heart failure, fatigue, and systemic metabolic alterations, including hypoglycemia. The endocrine pancreas is central to glucose homeostasis, however, the imp...

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Literature Corpus work: f23ab46e-3515-5af8-a329-d6d0da36f0ea
DOI: 10.1101/2024.06.28.601122

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