Article

Alpha cell dysfunction in early type 1 diabetes

2021-10-16

Abstract excerpt

<h4>Summary</h4> Multiple islet autoantibodies (AAb) predict type 1 diabetes (T1D) and hyperglycemia within 10 years. By contrast, T1D develops in just ∼15% of single AAb+ (generally against glutamic acid decarboxylase, GADA+) individuals; hence the single GADA+ state may represent an early stage of T1D amenable to interventions. Here, we functionally, histologically, and molecularly phenotype human islets from n...

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Literature Corpus work: f1e66549-73c6-537a-a563-6433d65a9c15
DOI: 10.1101/2021.10.15.464545

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