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Article

Pancreatic β-cell heterogeneity in health and diabetes: classes, sources, and subtypes.

American journal of physiology. Endocrinology and metabolism - 1 Apr 2021

Miranda Mario A, Macias-Velasco Juan F, Lawson Heather A

Abstract excerpt

Pancreatic β-cells perform glucose-stimulated insulin secretion, a process at the center of type 2 diabetes etiology. Efforts to understand how β-cells behave in healthy and stressful conditions have revealed a wide degree of morphological, functional, and transcriptional heterogeneity. Sources of heterogeneity include β-cell topography, developmental origin, maturation state, and stress response. Advances in...

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Identifiers

PMID: 33586491
DOI: 10.1152/ajpendo.00649.2020
PMCID: PMC8238131

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