Article
Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells.
Nature communications - 24 Nov 2016
Brereton Melissa F, Rohm Maria, Shimomura Kenju, Holland Christian, Tornovsky-Babeay Sharona, Dadon Daniela, Iberl Michaela, Chibalina Margarita V, Lee Sheena, Glaser Benjamin, Dor Yuval, Rorsman Patrik, Clark Anne, Ashcroft Frances M
Abstract excerpt
Insulin secretion from pancreatic β-cells is impaired in all forms of diabetes. The resultant hyperglycaemia has deleterious effects on many tissues, including β-cells. Here we show that chronic hyperglycaemia impairs glucose metabolism and alters expression of metabolic genes in pancreatic islets. In a mouse model of human neonatal diabetes, hyperglycaemia results in marked glycogen accumulation, and increased...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.