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Article

Targeted overactivity of beta cell K(ATP) channels induces profound neonatal diabetes.

Cell - 17 Mar 2000

Koster J C, Marshall B A, Ensor N, Corbett J A, Nichols C G

Abstract excerpt

A paradigm for control of insulin secretion is that glucose metabolism elevates cytoplasmic [ATP]/[ADP] in beta cells, closing K(ATP) channels and causing depolarization, Ca2+ entry, and insulin release. Decreased responsiveness of K(ATP) channels to elevated [ATP]/[ADP] should therefore lead to decreased insulin secretion and diabetes. To test this critical prediction, we generated transgenic mice expressing...

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Identifiers

PMID: 10761930
DOI: 10.1016/s0092-8674(00)80701-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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