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Article

Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes.

Diabetologia - 1 May 2021

Tornovsky-Babeay Sharona, Weinberg-Corem Noa, Ben-Haroush Schyr Rachel, Avrahami Dana, Lavi Judith, Feleke Eseye, Kaestner Klaus H, Dor Yuval, Glaser Benjamin

Abstract excerpt

AIMS/HYPOTHESIS: Acute hyperglycaemia stimulates pancreatic beta cell proliferation in the mouse whereas chronic hyperglycaemia appears to be toxic. We hypothesise that this toxic effect is mediated by increased beta cell workload, unrelated to hyperglycaemia per se. METHODS: To test this hypothesis, we developed a novel mouse model of cell-autonomous increased beta cell glycolytic flux caused by a conditional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33558985
DOI: 10.1007/s00125-021-05390-x
PMCID: PMC8117185

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