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Article

The association between the 5-HTTLPR and neural correlates of fear conditioning and connectivity.

Social cognitive and affective neuroscience - 1 May 2015

Klucken Tim, Schweckendiek Jan, Blecker Carlo, Walter Bertram, Kuepper Yvonne, Hennig Juergen, Stark Rudolf

Abstract excerpt

Strong evidence links the 5-HTTLPR genotype to the modulation of amygdala reactivity during fear conditioning, which is considered to convey the increased vulnerability for anxiety disorders in s-allele carriers. In addition to amygdala reactivity, the 5-HTTLPR has been shown to be related to alterations in structural and effective connectivity. The aim of this study was to investigate the effects of 5-HTTLPR...

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Identifiers

PMID: 25140050
DOI: 10.1093/scan/nsu108
PMCID: PMC4420749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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