Article
The functional -1019C/G HTR1A polymorphism and mechanisms of fear.
Translational psychiatry - 16 Dec 2014
Straube B, Reif A, Richter J, Lueken U, Weber H, Arolt V, Jansen A, Zwanzger P, Domschke K, Pauli P, Konrad C, Gerlach A L, Lang T, Fydrich T, Alpers G W, Ströhle A, Wittmann A, Pfleiderer B, Wittchen H-U, Hamm A, Deckert J, Kircher T
Abstract excerpt
Serotonin receptor 1A gene (HTR1A) knockout mice show pronounced defensive behaviour and increased fear conditioning to ambiguous conditioned stimuli. Such behaviour is a hallmark of pathological human anxiety, as observed in panic disorder with agoraphobia (PD/AG). Thus, variations in HTR1A might contribute to neurophysiological differences within subgroups of PD/AG patients. Here, we tested this hypothesis by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.