Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction of catechol O-methyltransferase and serotonin transporter genes modulates effective connectivity in a facial emotion-processing circuitry.

Translational psychiatry - 17 Jan 2012

Surguladze S A, Radua J, El-Hage W, Gohier B, Sato J R, Kronhaus D M, Proitsi P, Powell J, Phillips M L

Abstract excerpt

Imaging genetic studies showed exaggerated blood oxygenation level-dependent response in limbic structures in carriers of low activity alleles of serotonin transporter-linked promoter region (5-HTTLPR) as well as catechol O-methyltransferase (COMT) genes. This was suggested to underlie the vulnerability to mood disorders. To better understand the mechanisms of vulnerability, it is important to investigate the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amygdala
Share to Dominance, Cerebral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Facial Expression

Share to Image Interpretation, Computer-Assisted

Share to Limbic System

Share to Occipital Lobe

Share to Pattern Recognition, Visual

Share to Temporal Lobe

Source

Open in PubMed Open full text

Identifiers

PMID: 22832732
DOI: 10.1038/tp.2011.69
PMCID: PMC3309546

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction of catechol O-methyltransferase and serotonin transporter genes modulates effective connectivity in a facial emotion-processing circuitry.PMID 22832732Read ↗

The 5-HTTLPR Polymorphism Affects Network-Based Functional Connectivity in the Visual-Limbic System in Healthy Adults.Semantic proximity Read ↗

Genetic variation in the serotonin transporter modulates neural system-wide response to fearful faces.Semantic proximity Read ↗

5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression.Semantic proximity Read ↗

Catechol-O-methyltransferase Val(108/158)Met polymorphism affects fronto-limbic connectivity during emotional processing in bipolar disorderSemantic proximity Read ↗

Aversive stimuli lead to differential amygdala activation and connectivity patterns depending on catechol-O-methyltransferase Val158Met genotype.Semantic proximity Read ↗

Independent modulation of engagement and connectivity of the facial network during affect processing by CACNA1C and ANK3 risk genes for bipolar disorder.Semantic proximity Read ↗

Effects of the BDNF Val66Met polymorphism on neural responses to facial emotion.Semantic proximity Read ↗

Threat-related amygdala functional connectivity is associated with 5-HTTLPR genotype and neuroticism.Semantic proximity Read ↗

5-HTTLPR/rs25531 polymorphism and neuroticism are linked by resting state functional connectivity of amygdala and fusiform gyrus.Semantic proximity Read ↗

Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation.Semantic proximity Read ↗

Reduced amygdala-prefrontal coupling in major depression: association with MAOA genotype and illness severity.Semantic proximity Read ↗

Individual differences in amygdala-medial prefrontal anatomy link negative affect, impaired social functioning, and polygenic depression risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.