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Article

Neural mechanisms underlying 5-HTTLPR-related sensitivity to acute stress.

The American journal of psychiatry - 1 Apr 2012

Drabant Emily M, Ramel Wiveka, Edge Michael D, Hyde Luke W, Kuo Janice R, Goldin Philippe R, Hariri Ahmad R, Gross James J

Abstract excerpt

OBJECTIVE: Many studies have shown that 5-HTTLPR genotype interacts with exposure to stress in conferring risk for psychopathology. However, the specific neural mechanisms through which this gene-by-environment interaction confers risk remain largely unknown, and no study to date has directly examined the modulatory effects of 5-HTTLPR on corticolimbic circuit responses during exposure to acute stress. METHOD: An...

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Identifiers

PMID: 22362395
DOI: 10.1176/appi.ajp.2011.10111699
PMCID: PMC3761065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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