Article
Contributions of different kainate receptor subunits to the properties of recombinant homomeric and heteromeric receptors.
Neuroscience - 10 Oct 2014
Fisher M T, Fisher J L
Abstract excerpt
The tetrameric kainate receptors can be assembled from a combination of five different subunit subtypes. While GluK1-3 subunits can form homomeric receptors, GluK4 and GluK5 require a heteromeric partner to assemble, traffic to the membrane surface, and produce a functional channel. Previous studies have shown that incorporation of a GluK4 or GluK5 subunit changes both receptor pharmacology and channel kinetics....
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