Article
Contributions of different kainate receptor subunits to the properties of recombinant homomeric and heteromeric receptors.
Neuroscience - 10 Oct 2014
Fisher M T, Fisher J L
Abstract excerpt
The tetrameric kainate receptors can be assembled from a combination of five different subunit subtypes. While GluK1-3 subunits can form homomeric receptors, GluK4 and GluK5 require a heteromeric partner to assemble, traffic to the membrane surface, and produce a functional channel. Previous studies have shown that incorporation of a GluK4 or GluK5 subunit changes both receptor pharmacology and channel kinetics....
Topics
- Animals
- Binding Sites
- Glutamic Acid
- HEK293 Cells
- Humans
- Membrane Potentials
- Mutation
- Protein Subunits
- Rats
- Receptors, Kainic Acid
- Recombinant Proteins
- GluK2 Kainate Receptor