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Article

Structures of partially occupied hetero-tetramers provide insight into kainate receptor activation and desensitization.

Nature communications - 24 Apr 2026

Khanra Nandish K, Strauss Alexa, Moreno Wasielewski Laura, Lenze Sophie, Meyerson Joel, Reiner Andreas, Levitz Joshua

Abstract excerpt

Kainate receptors (KARs) are critical mediators and modulators of synaptic transmission which undergo rapid activation and desensitization upon binding of the neurotransmitter glutamate. Under various physiological and pharmacological conditions agonist binding likely occurs to only a subset of subunits within these tetrameric receptors, motivating an analysis of the functional and conformational effects of...

Topics

Kainic Acid Receptors
Cryoelectron Microscopy
Animals
GluK2 Kainate Receptor
Protein Multimerization
Models, Molecular
Humans
Protein Subunits
Protein Domains
Ligands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Binding Sites

Source

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Identifiers

PMID: 42031800
DOI: 10.1038/s41467-026-72226-w
PMCID: PMC13109363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-42031800-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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