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Article

Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization.

The EMBO journal - 20 May 2009

Chaudhry Charu, Weston Matthew C, Schuck Peter, Rosenmund Christian, Mayer Mark L

Abstract excerpt

AMPA and kainate receptors mediate fast synaptic transmission. AMPA receptor ligand-binding domains form dimers, which are key functional units controlling ion-channel activation and desensitization. Dimer stability is inversely related to the rate and extent of desensitization. Kainate and AMPA receptors share common structural elements, but functional measurements suggest that subunit assembly and gating...

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Identifiers

PMID: 19339989
DOI: 10.1038/emboj.2009.86
PMCID: PMC2688536

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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