Article
Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization.
The EMBO journal - 20 May 2009
Chaudhry Charu, Weston Matthew C, Schuck Peter, Rosenmund Christian, Mayer Mark L
Abstract excerpt
AMPA and kainate receptors mediate fast synaptic transmission. AMPA receptor ligand-binding domains form dimers, which are key functional units controlling ion-channel activation and desensitization. Dimer stability is inversely related to the rate and extent of desensitization. Kainate and AMPA...
Topics
- Amino Acid Sequence
- Crystallography, X-Ray
- Models, Biological
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Binding
- Protein Interaction Domains and Motifs
- Protein Multimerization
- Protein Structure, Quaternary
- Receptors, Kainic Acid