Article
The neurotoxin domoate causes long-lasting inhibition of the kainate receptor GluK5 subunit.
Neuropharmacology - 1 Oct 2014
Fisher Janet L
Abstract excerpt
Ionotropic glutamate receptors (iGluRs) are responsible for fast excitatory neurotransmission in the mammalian brain, and are critical regulators of neuronal activity and synaptic plasticity. The three main types of iGluRs (AMPA, NMDA, and kainate receptors) are composed of distinct subunit popul...
Topics
- 6-Cyano-7-nitroquinoxaline-2,3-dione
- Binding Sites
- Excitatory Amino Acid Antagonists
- Glutamic Acid
- HEK293 Cells
- Humans
- Kainic Acid
- Membrane Potentials
- Mutation
- Neural Inhibition
- Neurotoxins
- Patch-Clamp Techniques