Article
Agonist binding to the GluK5 subunit is sufficient for functional surface expression of heteromeric GluK2/GluK5 kainate receptors.
Cellular and molecular neurobiology - 1 Nov 2013
Fisher Janet L, Housley Paul R
Abstract excerpt
Trafficking of ionotropic glutamate receptors to the plasma membrane commonly requires occupation of the agonist binding sites. This quality control check does not typically involve receptor activation, as binding by competitive antagonists or to non-functional channels may also permit surface ex...
Topics
- 6-Cyano-7-nitroquinoxaline-2,3-dione
- Amino Acid Sequence
- Animals
- Binding Sites
- Cell Membrane
- Glutamates
- HEK293 Cells
- Humans
- Ligands
- Molecular Sequence Data
- Mutant Proteins
- Mutation
- Protein Binding
- Protein Multimerization
- Protein Subunits
- Rats
- Kainic Acid Receptors
- GluK2 Kainate Receptor