Article
Differential activation of individual subunits in heteromeric kainate receptors.
Neuron - 16 May 2002
Swanson Geoffrey T, Green Tim, Sakai Ryuichi, Contractor Anis, Che Wesley, Kamiya Hisao, Heinemann Stephen F
Abstract excerpt
Neuronal kainate receptors are assembled from subunits with dissimilar specificities for agonists and antagonists. The composite biophysical behavior of heteromeric kainate receptors is determined by intersubunit interactions whose nature is unclear. Here we use dysiherbaine, a selective kainate receptor agonist, to show that GluR5 subunits assembled in heteromeric GluR5/KA-2 kainate receptor complexes can gate...
Topics
- 6-Cyano-7-nitroquinoxaline-2,3-dione
- Alanine
- Binding Sites
- Bridged Bicyclo Compounds, Heterocyclic
- Cells, Cultured
- Central Nervous System
- Excitatory Amino Acid Agonists
- Excitatory Amino Acid Antagonists
- Glutamic Acid
- Humans
- Macromolecular Substances
- Models, Neurological