Article
Ligand binding is a critical requirement for plasma membrane expression of heteromeric kainate receptors.
The Journal of biological chemistry - 18 Feb 2005
Valluru Lokanatha, Xu Jian, Zhu Yongling, Yan Sheng, Contractor Anis, Swanson Geoffrey T
Abstract excerpt
Intracellular trafficking of ionotropic glutamate receptors is controlled by multiple discrete determinants in receptor subunits. Most such determinants have been localized to the cytoplasmic carboxyl-terminal domain, but other domains in the subunit proteins can play roles in modulating receptor surface expression. Here we demonstrate that formation of an intact glutamate binding site also acts as an additional...
Topics
- Animals
- Binding Sites
- Cell Line
- Cell Membrane
- Cells, Cultured
- Endoplasmic Reticulum
- Enzyme-Linked Immunosorbent Assay
- Hippocampus
- Humans
- Kainic Acid
- Ligands