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Article

The Drosophila F-box protein Fbxl7 binds to the protocadherin fat and regulates Dachs localization and Hippo signaling.

eLife - 8 Aug 2014

Bosch Justin A, Sumabat Taryn M, Hafezi Yassi, Pellock Brett J, Gandhi Kevin D, Hariharan Iswar K

Abstract excerpt

The Drosophila protocadherin Fat (Ft) regulates growth, planar cell polarity (PCP) and proximodistal patterning. A key downstream component of Ft signaling is the atypical myosin Dachs (D). Multiple regions of the intracellular domain of Ft have been implicated in regulating growth and PCP but how Ft regulates D is not known. Mutations in Fbxl7, which encodes an F-box protein, result in tissue overgrowth and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25107277
DOI: 10.7554/eLife.03383
PMCID: PMC4144329

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Drosophila F-box protein Fbxl7 binds to the protocadherin fat and regulates Dachs localization and Hippo signaling.PMID 25107277Read ↗

Separating planar cell polarity and Hippo pathway activities of the protocadherins Fat and Dachsous.Semantic proximity Read ↗

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The DHHC palmitoyltransferase approximated regulates Fat signaling and Dachs localization and activity.Semantic proximity Read ↗

The palmitoyltransferase Approximated promotes growth via the Hippo pathway by palmitoylation of Fat.Semantic proximity Read ↗

Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila.Semantic proximity Read ↗

Regulation of long-range planar cell polarity by Fat-Dachsous signaling.Semantic proximity Read ↗

Drosophila Dachsous and Fat polarize actin-based protrusions over a restricted domain of the embryonic denticle field.Semantic proximity Read ↗

Drosophila lowfat, a novel modulator of Fat signaling.Semantic proximity Read ↗

Vamana Couples Fat Signaling to the Hippo Pathway.Semantic proximity Read ↗

Regulation of cytoskeletal organization and junctional remodeling by the atypical cadherin Fat.Semantic proximity Read ↗

Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins.Semantic proximity Read ↗

Leading edge-secreted Dpp cooperates with ACK-dependent signaling from the amnioserosa to regulate myosin levels during dorsal closure.Semantic proximity Read ↗

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