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Article

Regulation of long-range planar cell polarity by Fat-Dachsous signaling.

Development (Cambridge, England) - 1 Sept 2013

Sharma Praveer, McNeill Helen

Abstract excerpt

Fat (Ft) and Dachsous (Ds) are large cadherins that bind each other and have conserved roles in regulating planar cell polarity (PCP). We quantitatively analyzed Ft-Ds pathway mutant clones for their effects on ommatidial polarity in the Drosophila eye. Our findings suggest that the Ft-Ds pathway regulates PCP propagation independently of asymmetric cellular accumulation of Ft or Ds. We find that the Ft effector...

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Identifiers

PMID: 23946440
DOI: 10.1242/dev.094730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of long-range planar cell polarity by Fat-Dachsous signaling.PMID 23946440Read ↗

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Signal transduction by the Fat cytoplasmic domain.Semantic proximity Read ↗

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The Drosophila F-box protein Fbxl7 binds to the protocadherin fat and regulates Dachs localization and Hippo signaling.Semantic proximity Read ↗

Separating planar cell polarity and Hippo pathway activities of the protocadherins Fat and Dachsous.Semantic proximity Read ↗

The DHHC palmitoyltransferase approximated regulates Fat signaling and Dachs localization and activity.Semantic proximity Read ↗

Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila.Semantic proximity Read ↗

Two frizzled planar cell polarity signals in the Drosophila wing are differentially organized by the Fat/Dachsous pathway.Semantic proximity Read ↗

Regulation of cytoskeletal organization and junctional remodeling by the atypical cadherin Fat.Semantic proximity Read ↗

The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor.Semantic proximity Read ↗

Transcriptional analysis of the dachsous gene uncovers novel isoforms expressed during development in Drosophila.Semantic proximity Read ↗

Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity.Semantic proximity Read ↗

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