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Article

Signal transduction by the Fat cytoplasmic domain.

Development (Cambridge, England) - 1 Feb 2013

Pan Guohui, Feng Yongqiang, Ambegaonkar Abhijit A, Sun Gongping, Huff Matthew, Rauskolb Cordelia, Irvine Kenneth D

Abstract excerpt

The large atypical cadherin Fat is a receptor for both Hippo and planar cell polarity (PCP) pathways. Here we investigate the molecular basis for signal transduction downstream of Fat by creating targeted alterations within a genomic construct that contains the entire fat locus, and by monitoring and manipulating the membrane localization of the Fat pathway component Dachs. We establish that the human Fat homolog...

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Source

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Identifiers

PMID: 23318637
DOI: 10.1242/dev.088534
PMCID: PMC3557778

Genes

FAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Signal transduction by the Fat cytoplasmic domain.PMID 23318637Read ↗

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