Article
The DHHC palmitoyltransferase approximated regulates Fat signaling and Dachs localization and activity.
Current biology : CB - 23 Sept 2008
Matakatsu Hitoshi, Blair Seth S
Abstract excerpt
Signaling via the large protocadherin Fat (Ft), regulated in part by its binding partner Dachsous (Ds) and the Golgi-resident kinase Four-jointed (Fj), is required for a variety of developmental functions in Drosophila. Ft and, to a lesser extent, Ds suppress overgrowth of the imaginal discs from which appendages develop and regulate the Hippo pathway [1-5] (reviewed in [6]). Ft, Ds, and Fj are also required for...
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