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Article

The palmitoyltransferase Approximated promotes growth via the Hippo pathway by palmitoylation of Fat.

The Journal of cell biology - 2 Jan 2017

Matakatsu Hitoshi, Blair Seth S, Fehon Richard G

Abstract excerpt

The large protocadherin Fat functions to promote Hippo pathway activity in restricting tissue growth. Loss of Fat leads to accumulation of the atypical myosin Dachs at the apical junctional region, which in turn promotes growth by inhibiting Warts. We previously identified Approximated (App), a DHHC domain palmitoyltransferase, as a negative regulator of Fat signaling in growth control. We show here that App...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28031421
DOI: 10.1083/jcb.201609094
PMCID: PMC5223609

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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The palmitoyltransferase Approximated promotes growth via the Hippo pathway by palmitoylation of Fat.PMID 28031421Read ↗

The DHHC palmitoyltransferase approximated regulates Fat signaling and Dachs localization and activity.Semantic proximity Read ↗

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The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size.Semantic proximity Read ↗

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