Article
Regulation of cytoskeletal organization and junctional remodeling by the atypical cadherin Fat.
Development (Cambridge, England) - 15 Jan 2013
Marcinkevicius Emily, Zallen Jennifer A
Abstract excerpt
The atypical cadherin Fat is a conserved regulator of planar cell polarity, but the mechanisms by which Fat controls cell shape and tissue structure are not well understood. Here, we show that Fat is required for the planar polarized organization of actin denticle precursors, adherens junction proteins and microtubules in the epidermis of the late Drosophila embryo. In wild-type embryos, spatially regulated...
Topics
- Actins
- Animals
- Cadherins
- Cell Adhesion
- Cell Adhesion Molecules
- Drosophila
- Drosophila Proteins
- Drosophila melanogaster
- Frizzled Receptors
- Gene Expression Regulation, Developmental
- Immunohistochemistry
- Microtubules
- Models, Genetic
- Mutation
- Receptors, Notch
- Time Factors