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Article

Elimination of B-RAF in oncogenic C-RAF-expressing alveolar epithelial type II cells reduces MAPK signal intensity and lung tumor growth.

The Journal of biological chemistry - 26 Sept 2014

Zanucco Emanuele, El-Nikhely Nefertiti, Götz Rudolf, Weidmann Katharina, Pfeiffer Verena, Savai Rajkumar, Seeger Werner, Ullrich Axel, Rapp Ulf R

Abstract excerpt

Tumors are often greatly dependent on signaling cascades promoting cell growth or survival and may become hypersensitive to inactivation of key components within these signaling pathways. Ras and RAF mutations found in human cancer confer constitutive activity to these signaling molecules thereby converting them into an oncogenic state. RAF dimerization is required for normal Ras-dependent RAF activation and is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25096573
DOI: 10.1074/jbc.M114.558999
PMCID: PMC4175323

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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