Article
Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling.
Molecular and cellular biology - 1 Feb 2010
Ritt Daniel A, Monson Daniel M, Specht Suzanne I, Morrison Deborah K
Abstract excerpt
The B-Raf kinase is a Ras pathway effector activated by mutation in numerous human cancers and certain developmental disorders. Here we report that normal and oncogenic B-Raf proteins are subject to a regulatory cycle of extracellular signal-regulated kinase (ERK)-dependent feedback phosphorylation, followed by PP2A- and Pin1-dependent dephosphorylation/recycling. We identify four S/TP sites of B-Raf...
Topics
- Animals
- Butadienes
- Enzyme Inhibitors
- Extracellular Signal-Regulated MAP Kinases
- Feedback, Physiological
- Humans
- MAP Kinase Kinase Kinases
- Mice
- Mutation
- NIH 3T3 Cells
- NIMA-Interacting Peptidylprolyl Isomerase