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Article

Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling.

Molecular and cellular biology - 1 Feb 2010

Ritt Daniel A, Monson Daniel M, Specht Suzanne I, Morrison Deborah K

Abstract excerpt

The B-Raf kinase is a Ras pathway effector activated by mutation in numerous human cancers and certain developmental disorders. Here we report that normal and oncogenic B-Raf proteins are subject to a regulatory cycle of extracellular signal-regulated kinase (ERK)-dependent feedback phosphorylation, followed by PP2A- and Pin1-dependent dephosphorylation/recycling. We identify four S/TP sites of B-Raf...

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Identifiers

PMID: 19933846
DOI: 10.1128/MCB.00569-09
PMCID: PMC2812223

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Source receipt: pubmed, retrieved 7 Sept 2026.

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