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Article

Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model.

Carcinogenesis - 1 Dec 2005

Floyd Heather S, Farnsworth Charles L, Kock Nancy D, Mizesko Melissa C, Little Joy L, Dance Stephanie T, Everitt Jeff, Tichelaar Jay, Whitsett Jeffrey A, Miller Mark Steven

Abstract excerpt

To determine the effects of expression of mutant Ki-ras on lung tumorigenesis, we developed a bitransgenic mouse model that expresses the human Ki-ras(G12C) allele in alveolar type II and/or Clara cells in a tetracycline-inducible, lung-specific manner. Expression of Ki-ras(G12C) caused multiple, small lung tumors over a 12-month time period. Although tumor multiplicity increased upon continued Ki-ras expression,...

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Identifiers

PMID: 16051643
DOI: 10.1093/carcin/bgi190
PMCID: PMC1351110

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