Article
Expression of dominant negative Erk2 inhibits AP-1 transactivation and neoplastic transformation.
Oncogene - 31 Dec 1998
Watts R G, Huang C, Young M R, Li J J, Dong Z, Pennie W D, Colburn N H
Abstract excerpt
The mitogen activated protein (MAP) kinases or extracellular signal-regulated kinases (Erks) are activated in response to Ras expression or exposure to tumor promoters or to growth factors, and have been implicated in AP-1 transactivation in some models. We have shown that tumor promoter induced activation of the transcription factor AP-1 is required for induced neoplastic transformation in the Balb/C JB6 cell...
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