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Article

Expression of B-RAF V600E in type II pneumocytes causes abnormalities in alveolar formation, airspace enlargement and tumor formation in mice.

PloS one - 1 Jan 2011

Zanucco Emanuele, Götz Rudolf, Potapenko Tamara, Carraretto Irene, Ceteci Semra, Ceteci Fatih, Seeger Werner, Savai Rajkumar, Rapp Ulf R

Abstract excerpt

Growth factor induced signaling cascades are key regulatory elements in tissue development, maintenance and regeneration. Perturbations of these cascades have severe consequences, leading to developmental disorders and neoplastic diseases. As a major function in signal transduction, activating mutations in RAF family kinases are the cause of human tumorigenesis, where B-RAF V600E has been identified as the...

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Identifiers

PMID: 22194995
DOI: 10.1371/journal.pone.0029093
PMCID: PMC3237599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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