Article
Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts.
Cancer research - 15 Dec 2005
Mercer Kathryn, Giblett Susan, Green Stuart, Lloyd David, DaRocha Dias Silvy, Plumb Mark, Marais Richard, Pritchard Catrin
Abstract excerpt
Mutations of the human B-RAF gene are detected in approximately 8% of cancer samples, primarily in cutaneous melanomas (70%). The most common mutation (90%) is a valine-to-glutamic acid mutation at residue 600 (V600E; formerly V599E according to previous nomenclature). Using a Cre/Lox approach, we have generated a conditional knock-in allele of (V600E)B-raf in mice. We show that widespread expression of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.