Article
A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation.
Molecular and cellular biology - 1 Mar 2003
Dhillon Amardeep S, Meikle Sharon, Peyssonnaux Carole, Grindlay Joan, Kaiser Christian, Steen Helge, Shaw Peter E, Mischak Harald, Eychène Alain, Kolch Walter
Abstract excerpt
It is widely thought that the biological outcomes of Raf-1 activation are solely attributable to the activation of the MEK/extracellular signal-regulated kinase (ERK) pathway. However, an increasing number of reports suggest that some Raf-1 functions are independent of this pathway. In this report we show that mutation of the amino-terminal 14-3-3 binding site of Raf-1 uncouples its ability to activate the...
Topics
- 14-3-3 Proteins
- 3T3 Cells
- Active Transport, Cell Nucleus
- Alleles
- Animals
- Binding Sites
- COS Cells
- Cell Differentiation
- Cell Division
- Cell Transformation, Neoplastic